Skin Disorders

Stable Vitiligo   Burns, Wounds, Ulcers    
 

Stable Vitiligo

Vitiligo is a skin condition in which there is a loss of pigmentation from the patch of skin. It occurs when melanocytes, the cells responsible for skin pigmentation, die or are unable to function. Melanocytes produce special substance called melanin which recognize body coloration and often called pigmenting substance of skin. It also protects the skin and underlying tissue from UV radiation. The underlying cause of vitiligo is unknown, but research suggests that it may arise from autoimmune, genetic, oxidative stress, neural, or viral causes.


Vitiligo is a common skin disease in India and affects about 2% of Indian population. Though the disease is cosmetic in nature, it has a lot of social stigma associated with it.

The choice of therapy depends on the number of white patches, their location, sizes, duration of occurance and how widespread they are. Each patient responds differently to therapy, and a particular treatment may not work for everyone. There are a number of treatments that improve the condition which includes medical therapies like topical steroid therapy, psoralen, photochemotherapy surgical therapies like autologous skin grafts, skin grafts using blisters, micropigmentation, autologous melanocyte transplants etc. Replenishing melanocytes selectively within vitiliginous macules by autologous melanocytes is a promising treatment. 

The autologus transplant used worldwide since long and the results are encouraging. Numerous studies have proved the effectiveness of melanocyte transplantation for the treatment of vitiligo. Transplantation of autologous  melanocytes has been reported as successful therapy for repigmentation of vitiliginous skin lesions.



At Stemcure, we provide services to the institute / Clinics / Clinician /CRO for stem cells development for stable vitiligo to conduct clinical trial for following conditions after obtaining regulatory approval.

 


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Burns, Wounds & Ulcers

The skin plays an important role in maintaining fluid and temperature regulation of the body. If large area of skin is injured, the ability to maintain that control can be lost. The skin also acts as a protective barrier against the bacteria and viruses that inhabit in the world outside the body. 

Burn

burn is a type of injury to flesh caused by heat, electricity, chemicals, light, radiation or friction. Most burns only affect the skin and rarely affect deeper tissues, such as muscle, bone, and blood vessels. Burns can cause swelling, blistering, scarring and, in serious cases, shock and even death. They also can lead to infections because they damage skin's protective barrier. 

wound is a type of injury in which skin is torn, cut or punctured (an open wound), or where blunt force trauma causes a contusion (a closed wound). It specifically refers to a sharp injury which damages the dermis of the skin. Minor wounds usually aren't serious, but cuts and scrapes require care. Serious and infected wounds require medical attention.


An ulcer is a sore on the skin or a mucous membrane, accompanied by the disintegration of tissue. Ulcers can result in complete loss of the epidermis and often portions of the dermis and even subcutaneous fat. Ulcers are most common on the skin of the lower extremities and in the gastrointestinal tract. An ulcer that appears on the skin is often visible as an inflamed tissue with an area of reddened skin. A skin ulcer is often visible in the event of exposure to heat or cold, irritation, or a problem with blood circulation. 



According to the American Burn Association, an estimated 500,000 burn injuries receive medical treatment yearly in the United States. In India about 700,000 people a year are admitted to hospital, though very few are looked after in specialist burn units. About 90% of burns occur in the developing world and 70% of these are in children. Survival from injuries covered greater than 40% total body surface area (TBSA) is rare in the developing world. 

Kertinocytes, the cells that make up 90% of the epidermis, can be cultured in vitro. Within the epidermis of skin, basal keratinocytes differentiate and stratify to form a multilayered structure with a surface cornified layer which limits water loss, and is also able to withstand minor mechanical, chemical and microbial injury. Keratinocytes produces many growth factors, matrix proteins, and basemant membrane proteins, which could be responsible for different aspects of wound healing. 

The culture of human epidermal keratinocytes has provided a powerful new tool in the field of skin biology since the pioneering work of Rheinwald and Green, who showed that it was possible to grow keratinocytes from a single cell suspension and to passage these cells serially. The clinical applications of such techniques become apparent following the use of cultured keratinocytes to treat two young burns victim in 1981. Since then number of reports have appeared concerning cultured autologous  cells in the treatment of burns and leg ulcers, although small numbers of patients have been involved. Studies suggest that epidermal keratinocytes can be used to graft epidermal defects including burns, chronic ulcers, epidermolysis bullosa and plastic surgery patients.

 

At Stemcure, we provide services to the institute / Clinics / Clinician /CRO for stem cells development for above condition to conduct clinical trial for following conditions after obtaining regulatory approval.


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