Spinal cord Injuries

Spinal cord injuries are known as the damage to the nerve roots inside the spinal cord which is responsible for carrying signals from the brain to any part of the body and vice versa.  

A spinal cord injury usually begins with a sudden, traumatic blow to the spine that fractures or dislocates vertebrae. Most injuries to the spinal cord don't completely sever it. Instead, an injury is more likely to cause fractures and compression of the vertebrae, which then crush and destroy the axons, extensions of nerve cells that carry signals up and down the spinal cord between the brain and the rest of the body. An injury to the spinal cord can damage a few, many, or almost all of these axons. Some injuries will allow almost complete recovery; others will result in complete paralysis.

Anyone can have spinal cord injury and there are various kinds and classification for it.  At present, standard spinal cord injury care focuses on urgent emergency care that is comprised of medications designed to reduce inflammation, immobilization designed to stabilize and align the spine and surgery to remove bone fragments, foreign objects, and damaged discs or vertebrae that are compressing the spine.

More than 50% of all cases of SCI occur in persons aged 16-30 years. Traumatic SCI is more common in persons younger than 40 years, while nontraumatic SCI is more common in persons older than 40 years. Greater mortality is reported in older patients with SCI. 44.5% people suffer due to motor vehicle accidents, 18.1% due to falls, 16.6% due to violence and 12.7% due to sports injury.

Stem cells hold potential for treating spinal cord injuries. Based on the findings from a large number of animal studies, scientists are working on the ways that stem cells may contribute to spinal cord repair:

stem cells may be used to replace the nerve cells that have died as a result of the injury.
stem cells may be used to generate new supporting cells that will re-form the insulating nerve sheath (myelin) and stimulate re-growth of damaged nerves.

Bone marrow cells release a variety of factors that stimulate neuronal growth from progenitor cells.  Studies have shown that bone marrow stem cells, hematopoietic stem cells and in vitro differentiated mesenchymal stem cells possess therapeutic effects on spinal cord injury.

Clinical studies on patients with spinal cord injury had shown improvement in bladder function as well as motor and/or sensory functions after administration of autologous bone marrow stem cells.

Umbilical cord and Wharton’s jelly derived mesenchymal stem cells (MSCs) are more potent as compared to bone marrow cells. Studies have shown that Wharton’s jelly derived MSCs when administered into spinal cord transaction led to improvements in movement of hips and thighs as well as increased sensory activities.

Human MSC are multipotent mesenchymal adult stem cells that have a potential for autologous transplantation, obviating the need for immune suppression. Although previous studies have established that MSC can be delivered to the injured spinal cord by lumbar puncture. Recent studies have reported that MSCs promote partial functional recovery after grafting to injury, sites although mechanisms underlying this recovery have not been defined. Grafted MSCs survived in spinal cord tissue, forming cell bridges within the traumatic centromedullary cavity. Animal studies have suggested that transplantation of bone marrow stem cells into spinal cord lesions enhances axonal regeneration and promotes functional recovery. Studies suggest that MSCs are immunosuppressive and reduces the acute inflammatory response to spinal cord injury and hence reduces cavity formation and astrocyte and macrophage reactivity.

At Stemcure, we provide services to the institute / Clinics / Clinician /CRO for stem cells development for spinal cord injuries to conduct clinical trial for following conditions after obtaining regulatory approval.